![]() ![]() Subsequently, both groups were offered vaccination with the mRNA-based Covid-19 vaccine from BioNTech/Pfizer and were monitored for almost two years. Both groups were comparable in relation to their sex, age, working conditions, and other risk factors. The researchers identified one group of people who had contracted SARS-CoV-2 during the first wave of the pandemic in spring 2020, and a second group who had not been infected. Since the beginning of the pandemic, 171 voluntary participants from the staff at the University Hospital rechts der Isar at risk of infection were recruited for the study and regularly tested. “Thus, we now know that while immunity built up or enhanced by vaccination is the most important key to effective protection against future variants of the virus, a breakthrough infection, as irritating as it may be, can provide the effect of an additional vaccine shot.” “Our study shows that triple-vaccinated individuals with no previous SARS-CoV-2 infection have almost the same amount of neutralizing antibodies as convalescents getting vaccinated or vaccinated individuals who had a breakthrough infection,” explains Ulrike Protzer. According to the study, this is possible in three constellations: after triple vaccination (basic immunization and booster), after infection and double vaccination, and after two vaccinations and a breakthrough infection. As they report in their new study, a total of three exposures is required to the spike protein as a viral antigen so that neutralizing antibodies form not only in sufficient quantity, but also in high quality. Keppler (Max von Pettenkofer Institute and Gene Center Munich at LMU) working together within the German Center for Infection Research (DZIF). New worrying variants are spreading rapidly: a challenge for physicians, as the question remains how to best protect people against infections with future virus variants.Īnswers to this question have been found by a team led by Ulrike Protzer (Institute of Virology at Helmholtz Munich and the Technical University of Munich), Percy Knolle (University Hospital rechts der Isar of the Technical University of Munich), and Oliver T. Since the beginning of the COVID-19 pandemic, the SARS-CoV-2 coronavirus continues to change. For the study, researchers from Helmholtz Munich, LMU and TUM followed the immunity of vaccinated and recovered individuals over two years. ![]() In this regard, a breakthrough infection with SARS-CoV-2 after two vaccinations achieves the same protective effect as an additional booster vaccination. These antibodies can also efficiently neutralize the omicron variant. A new study from Munich shows that the immune system develops a high-quality antibody response after a total of three encounters with the viral spike protein of SARS-CoV-2. ![]()
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